What is the result of extended periods of high doses of fluoride?

Extended periods of high doses of fluoride can lead to damage to bones, a condition known as skeletal fluorosis. When fluoride is consumed in excessive amounts over long periods, it can disrupt the normal bone remodeling process, leading to changes in bone structure and integrity. This may result in increased bone stiffness, pain, and in severe cases, even deformity. While fluoride is known for its benefits in preventing dental cavities at appropriate levels, excessive intake can have detrimental effects on bone health. This sharp contrast highlights the importance of balanced fluoride intake to maintain both dental and skeletal health.

Other potential effects of fluoride, such as improved dental health at recommended levels or enhanced bone density in controlled scenarios, don't typically occur with excessive fluoride. Similarly, increases in metabolic rate aren't directly linked to high fluoride exposure, reinforcing that appropriate management of fluoride levels is crucial for health.